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At the follow-up visit, after VLX was discontinued, 3 and 4 participants had worsening in their WI-NRS scores and PIS-Itch scores, respectively

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470 In animal models of Apelin-13-caused cardiomyocyte hypertrophy and heart failure, NCOA4-activated ferritinophagy leads to the upregulation of SFXN1 expression, causing mitochondrial iron overload and mitochondrial ROS overproduction, increased lipid peroxidation, and ultimately, ferroptosis

for the fasted-morning option, the dose goes in before the first food of the day, with breakfast held until the post-dose window has passed